[loginprakash]

What is the best method to break a O-Ph bond, specially when it is in the anomeric position of a sugar ? That too with a non participating neighbouring group(azide)

[discodermolide]

What is the best method to break a O-Ph bond, specially when it is in the anomeric position of a sugar ? That too with a non participating neighbouring group(azide)

A O-Ph bond will be hard to break. You might post the structure if you can?

[loginprakash]

i can send the structure ..but presently there r some problems to attach the image..in the server i suppose...will send it after it is resolved..

[loginprakash]

I am sorry it is not the O-Ph bond it is the R-OPh bond !!!

[Guitarmaniac86]

Is the group O-Ph or O-CH₂-Ph, because the latter can be cleaved by hydrogenation as it is an OBn group, O-Ph will be harder to cleave.

Is the reaction a glycoside that you are deprotecting?

[nox]

This Science paper from the Hartwig group might be of interest to you:

Selective, Nickel-Catalyzed Hydrogenolysis of Aryl Ethers

http://www.sciencemag.org/content/332/6028/439.abstract