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Topic: P-2 Nickel Reduction  (Read 1976 times)

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Offline AlphaScent

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P-2 Nickel Reduction
« on: August 17, 2012, 02:36:10 PM »
I just did a standard P-2 nickel reduction of an internal alkyne.  I got 74% yield.  Does that seem low to anyone who has done one? 
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Offline discodermolide

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Re: P-2 Nickel Reduction
« Reply #1 on: August 17, 2012, 02:39:14 PM »
Quote from: AlphaScent on August 17, 2012, 02:36:10 PM
I just did a standard P-2 nickel reduction of an internal alkyne.  I got 74% yield.  Does that seem low to anyone who has done one? 

Maybe a bit low but not bad for a first shot. Perhaps some over reduction?
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Offline AlphaScent

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Re: P-2 Nickel Reduction
« Reply #2 on: August 17, 2012, 03:18:12 PM »
No over reduction by GC.  Did not take an NMR though.  I think I can do better, next time.  Ill let you know.  Thanks Dan.
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