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Topic: Could you please explain why you need the ethanediol as the first step in this f  (Read 2435 times)

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Offline choupi

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Could you please explain why you need the ethanediol as the first step in this f
« on: September 17, 2012, 02:27:58 AM »
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« Last Edit: September 17, 2012, 08:02:12 AM by Arkcon »
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Offline discodermolide

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Re: Could you please explain why you need the ethanediol as the first step in this f
« Reply #1 on: September 17, 2012, 02:29:45 AM »
This is used to protect the ketone. It forms a 5-membered ring cyclic ketal.
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Offline orgopete

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Re: Could you please explain why you need the ethanediol as the first step in this f
« Reply #2 on: September 18, 2012, 11:28:43 PM »
Ketones are more reactive than epoxides. What would the product be if the ketal wasn't made first?
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Offline Babcock_Hall

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Re: Could you please explain why you need the ethanediol as the first step in this f
« Reply #3 on: September 19, 2012, 09:47:13 AM »
Quote from: discodermolide on September 17, 2012, 02:29:45 AM
This is used to protect the ketone. It forms a 5-membered ring cyclic ketal.
Is there an advantage in protecting a ketone in this way, as opposed to the dimethylacetal, for example?
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