[Nescafe]

Hi,

I am guessing not really since the negative charge is delocalized but I have seen it being nucleophilic. It is easy to deprotonate (pKa ~ 5). The reason I bring it up is because i would like to use it in a SN2 reaction and I am not sure how well it will do :S

Cheers,

Nescafe.

[discodermolide]

The alkali metal salts of tetrazole are good nucleophiles. Watch out though. Depending upon your tetrazole substitution the salt may be explosive. So don't isolate it keep it in solution.