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Removing Carbodiimide Bonds
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Topic: Removing Carbodiimide Bonds (Read 1766 times)
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david0925
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Removing Carbodiimide Bonds
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on:
September 27, 2012, 11:38:04 AM »
Hi all,
I am wondering if there are ways of breaking off the carbodiimide crosslinks formed using EDC-NHS, particularly through high pH (>14).
Thank you.
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mamid
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Re: Removing Carbodiimide Bonds
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Reply #1 on:
September 28, 2012, 09:24:34 AM »
Could you be just a little more specific?
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Babcock_Hall
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Re: Removing Carbodiimide Bonds
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Reply #2 on:
September 28, 2012, 10:30:41 AM »
Can you provide a structure?
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discodermolide
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Re: Removing Carbodiimide Bonds
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Reply #3 on:
September 28, 2012, 10:33:21 AM »
You could try heating in 30% NaOH solution. Although it it hard to suggest anything without some structural info.
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Removing Carbodiimide Bonds