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Topic: Which chlorinating agent is the best here and why?  (Read 3898 times)

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Offline Steenrod

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Which chlorinating agent is the best here and why?
« on: October 06, 2012, 09:04:54 AM »
Among the three reagents, PCl_5, PCl_3 and SOCl_2, which one is preferable in the production of alkyl halides from alcohols and why?

Thanks.This question came to my mind while studying about alkyl halides.
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Offline discodermolide

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Re: Which chlorinating agent is the best here and why?
« Reply #1 on: October 06, 2012, 09:21:26 AM »
There is not much to choose from here. It will depend a lot on your molecule.
My preference is for thionyl chloride.
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Offline orgopete

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Re: Which chlorinating agent is the best here and why?
« Reply #2 on: October 06, 2012, 04:23:27 PM »
I would guess that if all else were equal, thionyl chloride would be the reagent of choice as it is lower boiling and the by-products are gases. That may make isolation of your final product easier.
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