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Topic: Preventing Amide Hydrolysis by strong base  (Read 2070 times)

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Offline sam79

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Preventing Amide Hydrolysis by strong base
« on: October 13, 2012, 11:09:52 AM »
Hi

What are the techniques of preventing amide hydrolysis by a base like KOH and NaOH?
Should i make sure the solution is not too alkaline?(What Molar solution of base?)
 How low should the temperature be?


Regards
Sam
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Offline discodermolide

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Re: Preventing Amide Hydrolysis by strong base
« Reply #1 on: October 13, 2012, 11:22:16 AM »
Keep the base solution dilute, < 1.0M and do not heat it. A reaction temperature of 0-10°C should not cause amide hydrolysis.
What are the functional groups that you are trying to react?
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