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Topic: Acid Workup (Read 22237 times)
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Messi
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Acid Workup
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on:
November 06, 2012, 08:31:15 PM »
What is meant when someone says an acid workup?
I reacted my compound with TFA, would that be considered an acid workup?
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discodermolide
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Re: Acid Workup
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Reply #1 on:
November 06, 2012, 10:51:19 PM »
An acid work-up is where acid, usually a mineral acid or perhaps acetic acid depending really upon how acid stable your compound is, is used to remove basic components of a reaction mixture, or to re-protonate a basic compound.
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Messi
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Re: Acid Workup
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Reply #2 on:
November 07, 2012, 06:17:36 PM »
Ok, great. Is this done at the end of the reaction, at the extraction step?
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discodermolide
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Re: Acid Workup
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Reply #3 on:
November 07, 2012, 10:15:23 PM »
Not necessarily it can mean adding acid to the reaction to quench a reactive intermediate.
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