[Nescafe]

Hi,

I understand that this can vary from one protein to another but can we generally say that within the protein pocket statistically speaking there would be more chances of hydrogen and VW bonding interactions rather than ionic? So hydrogen bonding and vanderwall interactions between drug target play a dominant role in the interaction, however an ionic bond within the pocket will have a higher Strenght than a H bond?

So within the pocket ionic > hbond> VW in terms of Strenght but statistically H bonding and VW are more in number.

As for covalent bonds Ofcourse they are the strongest but preferably we don't want alkylating agents as drugs so I'm ignoring that.

Nescafé.

[Arkcon]

You can begin to figure this out by looking at the structure of the drug itself.  They're generally much simpler molecules.  You can see if derivatives, such as the various penicillin types, have the charged groups in common.  Then you can suspect the charged groups are important.