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Topic: hi can someone please check my reaction, synthesis of barbituric acid core  (Read 1350 times)

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Offline Sara87

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hi can someone please check my reaction, synthesis of barbituric acid core
« on: January 06, 2013, 10:50:08 AM »
please let me know its attached below
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Offline Dan

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Re: hi can someone please check my reaction, synthesis of barbituric acid core
« Reply #1 on: January 06, 2013, 11:40:47 AM »
Right idea, but take it one step at a time. The bis-anion you have drawn is not sensible in the presence of a base as weak as acetate.

Also check the mechanisms of substitution at carbonyl compounds (e.g. ester hydrolysis) - SN2, as you have drawn, does not occur.
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