[GSR]

Hi,

I am trying to react  a phenacyl bromide derivative with a thiol derivative  in MeoH/NaoH, the reaction did not took place even after 6 hrs (as it should happen ), can anybody suggest any alternative and/or quick method to this kind of reactions.

thanks in advance

GSR

[movies]

Ummm, that would react with the methanol solvent first!  If you want to acylate a thiol, you should go for a non-nucleophilic solvent (methylene chloride is good choice) and a non-nucleophilic base like triethylamine or pyridine.  If it's still sluggish, then you can use a catalyst like 4-(N,N-dimethylamino)pyridine (a.k.a. DMAP).

This reaction shouldn't take more than about 12-24 hours at the very most unless something fishy is going on.