[theanonymous]

Which one (Hydrocodone, Heroin, or Oxycodone) is made via nucleohphilic acyl substitution using one of the natural alkaloids as the nucleophile?

[theanonymous]

I don't know the answers to any of these...

[Arkcon]

Try looking up some of the compounds mentioned in part A.  You'll learn something about the nature of those drugs, you'll be able to answer the first part, and you'll also be on your way to understanding some of the rest.

[theanonymous]

Try looking up some of the compounds mentioned in part A.  You'll learn something about the nature of those drugs, you'll be able to answer the first part, and you'll also be on your way to understanding some of the rest.

I did try but there was a lot of information regarding them!
I have no idea why my teacher put this on our Webassign HW assignment because I dont see how it relates to what we're learning

[Arkcon]

I ssume from the title that some of this drugs are a natural product that is altered "via nucleohphilic acyl substitu ..."tion.   So why not try to see which are naturally occurring, and which are modified.  That should be the first sentence on Wikipedia.

[theanonymous]

I ssume from the title that some of this drugs are a natural product that is altered "via nucleohphilic acyl substitu ..."tion.   So why not try to see which are naturally occurring, and which are modified.  That should be the first sentence on Wikipedia.

What wikipedia page?

[discodermolide]

@theanonymous, you know better than to cry, sit down and look at the structures and the answers will be obvious. I assume you can also use search engines to find things such as Google.

What sort of compounds with what sort of functional groups form hydrochloride salts?

[theanonymous]

@theanonymous, you know better than to cry, sit down and look at the structures and the answers will be obvious. I assume you can also use search engines to find things such as Google.

What sort of compounds with what sort of functional groups form hydrochloride salts?

Is the answer to B heroin? since you can get an acyl group from that?

[discodermolide]

If you acylate morphine you get heroin.

[theanonymous]

If you acylate morphine you get heroin.

So the answer to B is heroin?

[discodermolide]

yes.

[theanonymous]

yes.

i had the logic right

[theanonymous]

So for the structure...would it be...

[discodermolide]

Yes you can use acetic anhydride or the acetyl chloride, either will work.

[theanonymous]

Yes you can use acetic anhydride or the acetyl chloride, either will work.

For C, would the answer be Carbon (C)? as in H is really bonded to carbon