Topic: Chemical Synthesis- need help (Read 3914 times)

lina12021 · « **on:** August 15, 2013, 06:08:09 AM »

How to synthesize 2-(Benzyloxy)cyclohexylamine from cyclohexene? (in 6 steps)

discodermolide · « **Reply #1 on:** August 15, 2013, 06:10:09 AM »

Have you got any ideas that you can share with us?

Dan · « **Reply #2 on:** August 15, 2013, 06:56:24 AM »

How to synthesize 2-(Benzyloxy)cyclohexylamine from cyclohexene? (in 6 steps)

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orgopete · « **Reply #3 on:** August 16, 2013, 10:41:22 AM »

An epoxide intermediate?

lina12021 · « **Reply #4 on:** August 20, 2013, 11:26:34 AM »

lina12021 · « **Reply #5 on:** August 20, 2013, 11:26:53 AM »

I've tried something.It is only idea, probably wrong. But anyway,I need one more step.

discodermolide · « **Reply #6 on:** August 20, 2013, 12:46:56 PM »

Try starting off by making an epoxide and see where you can go from there.

lina12021 · « **Reply #7 on:** August 20, 2013, 01:06:45 PM »

cyclohexane-1,2-diol...or halogencyclohexanol...and no idea about the next step

AlphaScent · « **Reply #8 on:** August 20, 2013, 01:51:35 PM »

you would not get the diol unless you hydrolyzed it. Do you know the reactivity of epoxides? What about an alkoxide?
Reductive amination?

discodermolide · « **Reply #9 on:** August 20, 2013, 06:19:56 PM »

cyclohexane-1,2-diol...or halogencyclohexanol...and no idea about the next step