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Topic: Question about methylphosphonate.  (Read 1872 times)

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Offline laura.g.berger

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Question about methylphosphonate.
« on: December 09, 2013, 11:03:08 AM »
Hi everybody!

Considering the molecule of methylphosphonate, i would like to know what kind of chemical reaction i could do to obtain ethylphosphonate, if is possible.

Thank you!
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Offline discodermolide

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Re: Question about methylphosphonate.
« Reply #1 on: December 09, 2013, 11:10:27 AM »
Do you require the acid or the diester?
O=P(O)(O)CC or O=P(OCC)(OCC)CC

The usual way is a Grignard reaction with PCl3 followed by alcoholysis and oxidation to give the ester, oxidation to get the acid.
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Offline orgopete

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Re: Question about methylphosphonate.
« Reply #2 on: December 10, 2013, 01:05:42 AM »
Arbusov
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Offline Babcock_Hall

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Re: Question about methylphosphonate.
« Reply #3 on: December 10, 2013, 09:05:32 AM »
Is this an intellectual exercise, or are you trying to make it?  There are commercial sources.
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