[Tushare]

Hey all I would like to find a way to manipulate the intracellular pH of a cell without affect all the cells in my culture. I know I can use a number of approaches to acidify of alkalinize my culture be I was hoping to find a method that would involve the transfection of something genetically encoded. This would give me modulation of intracellular pH in a small percentage of my cells in my culture. I was thinking a poly histadine linked to a fluorescent marker (GFP) or maybe using aspartic or glutamic acid would be more effective? Any thoughts would be much appreciated.
 
Cheers,