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Topic: Interchanging THF with Acetone ?  (Read 1281 times)

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Offline organosurf

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Interchanging THF with Acetone ?
« on: March 04, 2014, 11:02:17 AM »
In a certain reaction to reduce a primary alkyl halide to its alkane, Zinc, aqueous NH4Cl in THF at room temp are employed. THF does not form any complexes or intermediates in the reaction.
THF is a polar nonprotic solvent; so is acetone ( apart from their dielectric constants, acetone is regarded comparatively as a weak acid due to its methylene group, etc ).
For the above reaction, can acetone be substituted for THF ?
How about using Isopropyl alcohol ( IPA ) that is used as a proton donor in some organic reductions ?


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