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Topic: Esterification of Valproic Acid with Decanoic Acid  (Read 2773 times)

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Offline NeuroDoc

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Esterification of Valproic Acid with Decanoic Acid
« on: September 25, 2014, 07:56:02 PM »
Not a chemist but a curious physician. Need advice -

Is it possible to combine valproic acid (http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3121&loc=ec_rcs) and decanoic acid (http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2969&loc=ec_rcs) via esterification of the carboxyl group on valproic acid?

Thanks.

Offline Babcock_Hall

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Re: Esterification of Valproic Acid with Decanoic Acid
« Reply #1 on: September 26, 2014, 09:33:53 AM »
I may not be understanding your question fully, but the only functional group on either molecule is a carboxylic acid.  In principle one could join them, but the linkage would be a carboxylic acid anhydride (or just anhydride for short).

Offline discodermolide

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Re: Esterification of Valproic Acid with Decanoic Acid
« Reply #2 on: September 26, 2014, 10:34:04 AM »
A curious chemist would like to know what this will achieve?
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Offline TheUnassuming

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Re: Esterification of Valproic Acid with Decanoic Acid
« Reply #3 on: September 27, 2014, 04:22:18 PM »
Could you combine the two... yes... though not through esterification. 
Second disco's curiosity in to why you want to know this before going further.  I know valproic acid has some interesting physiological activity, what are you hoping to do with the decanoic acid attached to it?
When in doubt, avoid the Stille coupling.

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