November 28, 2024, 05:35:30 AM
Forum Rules: Read This Before Posting


Topic: Biochemistry General Question  (Read 2316 times)

0 Members and 1 Guest are viewing this topic.

Offline limonade

  • Regular Member
  • ***
  • Posts: 89
  • Mole Snacks: +4/-2
Biochemistry General Question
« on: January 24, 2015, 09:47:24 PM »
I know the  B cells use class II MHC proteins to present antigens, but they also contain MHC I proteins. What is the function of MHC I in these  B  immune system cells?

Thanks in advance

Evolutionary carryover? Usage of MHC I for recognition by cytotoxic T cells in case the B cells are somehow dysfunctional and need to be destroyed?
« Last Edit: January 24, 2015, 10:04:39 PM by limonade »

Offline Babcock_Hall

  • Chemist
  • Sr. Member
  • *
  • Posts: 5707
  • Mole Snacks: +330/-24
Re: Biochemistry General Question
« Reply #1 on: January 27, 2015, 10:16:17 AM »
I am not an expert in the immune system, but my understanding is that all cells have MHC I proteins.  My understanding is that class I and class II present peptides from different sources.  Class I peptides derive from (mainly?) cytoplasm, and Class II peptides derive from (mainly?) extracellular sources:  http://www.cryst.bbk.ac.uk/pps97/assignments/projects/coadwell/MHCSTFU1.HTM
« Last Edit: January 27, 2015, 10:46:25 AM by Babcock_Hall »

Sponsored Links