I can only guess what translation problems you're having, but this is a pretty obtuse paper to start with. A quick skim of the paper leads me to believe that the author may have even coined the term "frustration" to mean "computational difficulties in modeling biophysical phenomena." But I don't know if anyone else has faced the same term. It seems he's starting with an XKCD cartoon on a similar subject, so this may be a well known computing or mathematics concept.