[RVV]

Would you be so kind as to help me with understanding of notion of frustration in biomolecules in common?
I tried to translate articles (like http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256721) but I can not grasp the essence. Very "frustrated" 

I'm foreigner, so forgive me for my English and if I incorrectly chosen forum

[Arkcon]

I can only guess what translation problems you're having, but this is a pretty obtuse paper to start with.  A quick skim of the paper leads me to believe that the author may have even coined the term "frustration" to mean "computational difficulties in modeling biophysical phenomena."  But I don't know if anyone else has faced the same term.  It seems he's starting with an XKCD cartoon on a similar subject, so this may be a well known computing or mathematics concept.

[Arkcon]

Apparently, another term that can be used is "combinational optimism"  http://www.explainxkcd.com/wiki/index.php/173:_Movie_Seating

[RVV]

But what about http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048099/ and "principle of minimal frustration" (from article "Protein folding" from Wikipedia: http://en.wikipedia.org/wiki/Protein_folding)?
Also it is localised (also confused) in proteins: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394345/  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148382/

P.S.:I should to do presentation about frustration in proteins.
However thank You for answering!!!

[Arkcon]

Thank you for initiating this topic.  I suppose you will have to find more references to the minimal frustration principle from a variety of references, and see if you can build a complete discussion around it.

http://www.explainxkcd.com/wiki/index.php/1430:_Proteins

[Corribus]

http://www.explainxkcd.com/wiki/index.php/1430:_Proteins

Lol, never even knew about this wiki!