[kingkongpingpong]

Would it be correct to assume that since infliximab is a monoclonal antibody (and is simply huge in size) it would have no stereochemistry? I've researched this for hours and come up with nothing.

[Dan]

Would it be correct to assume that since infliximab is a monoclonal antibody (and is simply huge in size) it would have no stereochemistry?

On what theoretical basis do you make this assumption?

[Arkcon]

Why is stereochemistry important?  I realize its an inherent property of a compound, but why do we care about stereochemistry?  Why is it that the D or L form of a drug, or of a nutrient matters?

[kingkongpingpong]

My theoretical assumption is dumbfounded. I realize that size does not matter with respect to stereochemistry.

I thought the stereochemistry is important in that different isomers elicit different biologic functions.

Nevertheless, how would I go about finding the stereochemistry of this molecule?

[Babcock_Hall]

To what general class of macromolecules do antibodies belong?

[kingkongpingpong]

Proteins!

[Babcock_Hall]

And proteins are polymers of amino acids.  Sounds as if you have it now.

[Arkcon]

I thought the stereochemistry is important in that different isomers elicit different biologic functions.

Why?  What is the source of the difference biological effect between two isomers?  What does one isomer do, and another one not do?  Where does this all (spoiler) fit?

Nevertheless, how would I go about finding the stereochemistry of this molecule?

What happens if a molecule has two stereochemical sites?  Now picture if there are more.