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Topic: About Click Chemistry  (Read 1622 times)

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Offline darkdevil

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About Click Chemistry
« on: October 01, 2015, 11:49:58 AM »
Hi,
I read a lot of literatures about the click chemistry between an alkyne and an azide. I just wonder if it is possible for alkene and azide to undergo such cycloaddition reaction?
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Offline TheUnassuming

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Re: About Click Chemistry
« Reply #1 on: October 01, 2015, 12:03:43 PM »
Indeed it is, under certain circumstances. 

Check out this paper: J. Am. Chem. Soc. 2015, 137, 2958−2966
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When in doubt, avoid the Stille coupling.
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