[Dan]

Does anyone know how to refine a structure answer set to natural products in SciFinder?

This is a handy check box in Reaxys, but I no longer have access to Reaxys and can't work out how to do it in SciFinder...

[TheUnassuming]

This is one problem I've never found a suitable solution for and is a big weakness for the search engine.  Even if you could narrow chem structure results by those reported in journal X, it would help.  Unfortunately that feature is only available in the reaction searching platform.

[Guitarmaniac86]

How do you do that in Reaxsys? I never knew it could do that!?

[phth]

Maybe by journal type.  If a product is extracted from X bacteria, then it will be reported as not a synthesis.   Refine by polyketide?...hope this helps.  There are still a plethora of natural products that haven't  been synthesized yet.  Heres an example that probably wont be synthesized lol:      Fenical, W.; Jensen, P. R.; Nature Chemical
Biology. 2006, 12, 2, 666-673.

[Dan]

Maybe by journal type.  If a product is extracted from X bacteria, then it will be reported as not a synthesis.   Refine by polyketide?...

I am using these kinds of workarounds already, but it's far from ideal. It's much more time consuming and less comprehensive than just ticking a box to limit the results to anything isolated from a natural source.

Interesting you chose an enediyne, I am working on these at the moment...