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Topic: Urgent retrosynthesis and subsequent synthesis  (Read 2005 times)

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Offline caanmaro

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Urgent retrosynthesis and subsequent synthesis
« on: November 20, 2015, 09:48:21 PM »
Good morning
I need to know how do you develop the retrosynthesis and the synthesis of the two molecules following?

Deputy my proposals,

I hope your important comments

Thank you
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Offline beardy

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Re: Urgent retrosynthesis and subsequent synthesis
« Reply #1 on: November 21, 2015, 12:31:47 AM »
First retrosynthetic route in your second problem can be handled with an aldol condensation. Your bond-breaking indication is correct, but your subsequent step is wrong. Are you familiar with aldol condensation/enolates?



Are you starting with benzene or phenol in problem 2? You can take advantage of diazonium in electrophilic aromatic substitution to dictate substituent positioning.

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Offline orgopete

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Re: Urgent retrosynthesis and subsequent synthesis
« Reply #2 on: November 21, 2015, 01:04:26 AM »
Can bromoacetoacetate self-condense?
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Offline caanmaro

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Re: Urgent retrosynthesis and subsequent synthesis
« Reply #3 on: November 22, 2015, 07:49:03 AM »
Good Morning

I did the synthesis of the two molecules, This proposal is feasible?
Thank you very much
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