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Topic: asymmetric reduction of alphaketo acid  (Read 1754 times)

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Offline AlphaScent

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asymmetric reduction of alphaketo acid
« on: February 08, 2016, 04:36:38 PM »
Does anyone have a good review of the Corey-Bakshi-Shibata reaction?  I am having trouble finding a review that includes the alpha-ketoacids.  I have found a paper (see attached) that details the use of Ipc2BH as a stereoselective reductant giving 77% ee. 

The compound I am trying to do reduce is alpha-ketoglutarate. 

Any thoughts or suggestions would be greatly appreciated!!

Cheers!!
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Offline AlphaScent

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Re: asymmetric reduction of alphaketo acid
« Reply #1 on: February 08, 2016, 04:37:49 PM »
I forgot it is against forum rules to attach PDF's

here is a link to it

http://www.ncbi.nlm.nih.gov/pubmed/12126421
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Offline zarhym

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Re: asymmetric reduction of alphaketo acid
« Reply #2 on: February 09, 2016, 07:57:55 AM »
Noyori asymmetric hydrogenation. I'll try start searching this first.
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