[olly2323]

So I want to add a keto group (-COCH2CH2CH3) to bromo benzene in the place of the bromine. Do i need to make an organometallic and then an acyl chloride?

Thanks for your help.

[Babcock_Hall]

Which organometallic reagent would you use?

[olly2323]

Which organometallic reagent would you use?

I was thinking possibly adding magnesium?

[Babcock_Hall]

A Grignard reagent may not work in this instance, because you might get addition to the ketone.  I would look at other organometallic reagents.  BTW do you have to start with the bromine-derivative, or could you use something else?

[olly2323]

Could start with something else.

[olly2323]

What would you suggest, I dont really know?

[Arkcon]

I'd like to welcome you, olly2323:, to the Chemical Forums, but I'm going to ask you to read the Forum Rules{click}

This is a learning forum, we like to help people help themselves.  You'll have to arrive with some of the basics, and be able to respond to a hint.  Can you start with something you've learned recently?  You wanted to "add magnesium" , but Babcock_Hall: suggests a Grignard reagent wouldn't work.  Do you know what a Grignard reagent is, and how it works?  Can you find out in your textbook or class notes?  Its not likely you've been assigned a moderately advanced organic synthesis, without having had some prior instruction.

[Arkcon]

Oh, by the way, a common name for your assigned reagent is Butyrophenone, and its a common starting point for many medicines.  https://en.wikipedia.org/wiki/Butyrophenone  I hope you'll pay attention to the forum rules, and remember to keep this discussion firmly in the "school assignment" mode.

[critzz]

The grignard reaction might work if you use the weinreb amide of your keto group instead of an acyl chloride.

https://en.wikipedia.org/wiki/Weinreb_ketone_synthesis

[zarhym]

Oh, by the way, a common name for your assigned reagent is Butyrophenone, and its a common starting point for many medicines.  https://en.wikipedia.org/wiki/Butyrophenone  I hope you'll pay attention to the forum rules, and remember to keep this discussion firmly in the "school assignment" mode.

Your target molecule is indeed commercially available and inexpensive.
However, if you still have to do this for some reason, I will suggest this method.
http://www.organic-chemistry.org/abstracts/lit2/214.shtm