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Topic: Mechanism help (Read 1572 times)
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peas2007
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Mechanism help
«
on:
May 09, 2016, 01:35:20 PM »
Hi all, can someone help me figure out how to start with a mechanism for this reaction? I'm at a loss of where to start. Does the OH attack the carbonyl first? Or does EtOH attack first?
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OCSaviour
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Re: Mechanism help
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Reply #1 on:
May 09, 2016, 03:18:01 PM »
The EtOH reacts first. Then the acid protonates either of the OH groups and intermolecular reaction takes place.
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TheUnassuming
Chemist
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Re: Mechanism help
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Reply #2 on:
May 10, 2016, 08:37:58 AM »
OP: Have you learned about intramolecular vs intermolecular reaction rates?
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When in doubt, avoid the Stille coupling.
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