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Topic: finasteride solution stability  (Read 3689 times)

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tms5d

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finasteride solution stability
« on: September 06, 2016, 02:10:49 AM »
Hi, for an upcoming science experiment I'd like to know, if a 60/40 v/v ethanol/demi water Finasteride (N-(1,1-dimethylethyl)-3-oxo-
(5α,17β)-4-azaandrost-1-ene-17-carboxamide) solution will be stable for the duration of about two months. Or put differently, is there any Finasteride degredation (ie reaction with) from water to be expected?

Thank you very much.

Offline AWK

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Re: finasteride solution stability
« Reply #1 on: September 06, 2016, 03:07:54 AM »
Solution of finasteride with minoxidil can be found in market. Mixture of ethanol, glycerin and water is used as solvent. Amount in bottle is for 2 month topical using. What does it mean?
AWK

tms5d

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Re: finasteride solution stability
« Reply #2 on: September 06, 2016, 05:53:59 AM »
Solution of finasteride with minoxidil can be found in market. Mixture of ethanol, glycerin and water is used as solvent. Amount in bottle is for 2 month topical using. What does it mean?

I did not know that, thanks. I guess that means, that this solution is stable. Do you know if there any scientific studies done on this subject? Or, looking at the Finasteride molecule, is there any reactivity to be expected with water?

Offline AWK

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Re: finasteride solution stability
« Reply #3 on: September 06, 2016, 06:20:25 AM »
Solution of finasteride with minoxidil can be found in market. Mixture of ethanol, glycerin and water is used as solvent. Amount in bottle is for 2 month topical using. What does it mean?

I did not know that, thanks. I guess that means, that this solution is stable. Do you know if there any scientific studies done on this subject? Or, looking at the Finasteride molecule, is there any reactivity to be expected with water?
AWK

Offline AWK

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Re: finasteride solution stability
« Reply #4 on: September 06, 2016, 06:24:17 AM »
Quote
looking at the Finasteride molecule, is there any reactivity to be expected with water
Finasteride has two amide bonds and one double bond conjugated with carbonyl group. They are not very reactive, but on prolonged time or in stronger basic or alkaline solutions may undergo reactions.
AWK

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