[HailoMan]

Apology in advanced if this is a silly question, but in calibrating 1H NMR spectra, can I use water residue as a reference instead of the internal solvent residue?
I did a 1H NMR measurement of gamma-valerolactone (GVL) in DMSO-d6. The DMSO residue peak (2.50 ppm) happen to overlap with 2 of the proton peaks of GVL, so I can't use the DMSO as an internal standard.

[discodermolide]

Surely this compound should be soluble in chloroform? Then you can use that as the reference.

[Babcock_Hall]

The chemical shift of water depends upon temperature; therefore, one would have to take this into account.

[HailoMan]

Surely this compound should be soluble in chloroform? Then you can use that as the reference.

Unfortunately, the compound (nitrogen-doped carbon nanotubes) is non-dispersible in chloroform or other common NMR solvents.

The chemical shift of water depends upon temperature; therefore, one would have to take this into account.

Thank you for this information. I will look into it.

[Dan]

Why not just add an internal reference that does not overlap with anything - e.g. tetramethylsilane at 0 ppm?