[mattp]

Hello everyone,

I am looking up at the S_EAR of acetanilide with bromine to give p-Bromoacetanilide.
In my protocol they use acetic acid to dissolve the acetanilide. Im a wondering if it wouldn't also "activate" the heterolytic fission of Br₂ al we also dissolve bromine in some acetic acid. If so, how does this happen ?

Also, the protocol states that at low temperatures the para position is preferred rather than the ortho position and i was wondering why as a low temp the amide next to the phenyl group rotates less and so we would get less steric hindrance than at high temp?

Many thanks!