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Topic: synthetic analysis  (Read 1971 times)

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Offline girl101

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synthetic analysis
« on: November 22, 2016, 04:05:45 PM »
i am truly lost is reagent A an amine ? to combat the aldol reaction with base. ? how did they go from 5 ring to 6 ring and conjugated .please help  ???
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Offline Vidya

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Re: synthetic analysis
« Reply #1 on: November 22, 2016, 06:38:33 PM »
Your question is slightly not clear ... Can you show your attempt?
Aldol reaction can take place in acidic medium  also .Don't you think it is aldol followed by nucleophilic substitution in step II and III.What do you think?
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Offline Babcock_Hall

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Re: synthetic analysis
« Reply #2 on: November 23, 2016, 09:54:44 AM »
If Reagent A were an amine, what would you form, and what would its utility be?
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Offline Dan

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Re: synthetic analysis
« Reply #3 on: November 23, 2016, 12:05:49 PM »
Also, I think there is an error and compound IV should be (one methylene fewer):

c1ccccc1CC(C(=O))C2CCCC2
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