[raohonghua]

When I am carrying the suzuki reactions using NiCl2-6H2O as the catalyst and Bpy as the ligand, however, I did not get the product but the homocoupling of Ar-B(OH)2. Would you please tell me what is the problem? Thank you very much! By the way, I am a freshman at this forum.

[Dan]

Is there any specific reason you are using a Ni catalyst? I was under the impression that Pd(PPh₃)₄ is the standard catalyst for Suzuki coupling (generated in situ from Pd(II) acetate). I have sucessfully carried out a Suzuki coupling in this way.

[Will]

I was under the impression that Pd(Ph₃)₄ is the standard catalyst for Suzuki coupling (generated in situ from Pd(II) acetate). I have sucessfully carried out a Suzuki coupling in this way.

Do you mean Pd(PPh₃)₄?

[Dan]

Yes I do! Not the horrific complex I suggested - I have corrected it.

[ethylacetate]

?

[heyjude22]

I would suggest using Pd(PPh₃)₄ for a Suzuki coupling.  In my experience, it has always worked pretty well.  Another thing to consider is changing the base you use.  This can facilitate the transmetallation step and increase the rate of reaction.

[PRIYA1022]

 Suzuki reactions are also carried out with Nickel in place of palladium. I would suggest a ligand change. Try this reference..J. Org. Chem., Vol. 62, No. 23, 1997.page 8024 and J. Org. Chem. 1996, 60,pages 1060.

[CDW101057]

The following condition: tris(dibenzylideneacetone)dipalladium(0), tri-tert-butylphosphine and anyhydryous cerium cabonate might be a better choice.

[movies]

Those conditions work best under conditions where you can get beta-hydride elimination.  The tetrakis conditions are a lot more convenient and cheaper though!