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Topic: Solubility of trifluoro acetamide?  (Read 2065 times)

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Offline rolnor

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Solubility of trifluoro acetamide?
« on: July 25, 2018, 10:13:07 PM »
Does anybody know the watersolubility of trifluoroacetamide? I have looked in Handbook and Merckś index but I cant find anything. Acetamide is very soluble and my guess is also the trifluoro derivative should be watersoluble.
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Offline pgk

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Re: Solubility of trifluoro acetamide?
« Reply #1 on: July 26, 2018, 11:36:34 AM »
According to the Merck Company, the water solubility of 2,2,2-trifluorocetamide is 460 g/l at 23 oC, as figuring in the corresponding Material Safety Data Sheet (MSDS).
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Offline rolnor

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Re: Solubility of trifluoro acetamide?
« Reply #2 on: July 26, 2018, 07:42:50 PM »
Thank you pgk, then it should be OK to wash it out from toluene with water.
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Offline pgk

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Re: Solubility of trifluoro acetamide?
« Reply #3 on: July 27, 2018, 11:01:45 AM »
Yes but you have to wash toluene with water several times because its logP ≈ 0.15, which means that trifluoroacetamide is both soluble in water and in organic solvents, as having a logP value around 0.
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