[fluere enthusiast]

I have synthesised 2-ethyl-3-fluoropyridine (~900 mg), purified it with NP flash chromatography and attempted to vac down the EtOAc and cyclohexane. However, appears my product is volatile and even concentrating at 50 deg 380 mbar I still lose product to the splash trap and waste.

Anyone have any suggestions on how to effectively remove the solvents on a rotovap without losing any more product? Thanks.

[OrganicDan96]

try to find a lower boiling solvent mixture like ether and pentane, use a much lower bath temp. i suspect you will always lose some on the rotovap

[wildfyr]

You could do it ass-backwards an extract into a high boiling solvent and then fractionally distill off the product. Don't use a rotovap use an actual fractional distillation setup