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Topic: Adipoyl Chloride synthesis  (Read 4118 times)

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Offline nylonnnnn

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Adipoyl Chloride synthesis
« on: March 25, 2019, 09:02:23 PM »
Hi, does anyone know the chemical equation for the reaction between adipic acid and thionyl chloride to form adipoyl chloride.
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Offline wildfyr

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Re: Adipoyl Chloride synthesis
« Reply #1 on: March 26, 2019, 02:21:25 AM »
You should look up the reaction between thionyl chloride and any carboxylic acid. It's well known and very general.
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Offline Babcock_Hall

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Re: Adipoyl Chloride synthesis
« Reply #2 on: March 26, 2019, 12:23:55 PM »
I would pay attention to stoichiometry as well.
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Offline wildfyr

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Re: Adipoyl Chloride synthesis
« Reply #3 on: March 28, 2019, 01:03:44 PM »
Most thionyl chloride reactions are run with large excesses of thionyl chloride aka its the solvent. I usually add a drop of catalytic DMF. chlorinations like this can even work heterogeneously (the starting material not being soluble in SOCl2).
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