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Topic: help with a reaction  (Read 4807 times)

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Offline tawabj

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help with a reaction
« on: August 09, 2006, 03:24:35 PM »
For the retrosynthetic analysis of the target ketone (butane with double bond O at caron 2) what the target molecule?

     
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Offline tksubbu

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Re: help with a reaction
« Reply #1 on: August 09, 2006, 04:26:35 PM »
Reterosynthesis
2-Butanone => 2-Butanol => acetaldehyde (CH3CHO) + ethyl MgBr (CH3CH2 MgBr)

synthesis:
Ethyl Bromide + Mg in ether --> Et MgBr

CH3CHO + Et MgBr --> CH3CH(OH)CH2CH3

CH3CH(OH)CH2CH3 + KMnO4 --> CH3COCH2CH3
 
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Offline edwin

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Re: help with a reaction
« Reply #2 on: August 19, 2006, 08:28:52 PM »
Also, you can synthesis target in one-step reaction:
Butanone=>Propionitrile + ethyl MgBr

synthesis:

Ethyl Bromide + Mg --> Et MgBr

CH3CH2CN + Et MgBr -->[ CH3C(=N-MgBr)CH2CH3]----->hydrolyzed with acid aq.  CH3COCH2CH3

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